{"id":6231,"date":"2019-09-27T08:00:11","date_gmt":"2019-09-27T12:00:11","guid":{"rendered":"https:\/\/www.simonssearchlight.org\/?page_id=6231"},"modified":"2019-09-27T08:00:11","modified_gmt":"2019-09-27T12:00:11","slug":"6231-2","status":"publish","type":"page","link":"https:\/\/www.simonssearchlight.org\/research\/what-we-study\/med13l-2\/6231-2\/","title":{"rendered":""},"content":{"rendered":"<h2><strong>De novo gene disruptions in children on the autistic spectrum<\/strong><\/h2>\n<p>Original research article by E.M. Iossifov <em>et al.<\/em> (2012).<\/p>\n<p>Read the abstract <a href=\"https:\/\/www.nature.com\/articles\/mp2013127\">here<\/a>.<\/p>\n<p>In this study, 343 families from the <span class=\"notranslate\">Simons Foundation<\/span>\u2019s Simons Simplex Collection, who have at least one child with a diagnosis of autism, were tested with whole-exome sequencing. This study identified 350-400 new candidate genes that may be related to the features of autism, including\u00a0MED13L. A change that is believed to cause the gene to not work correctly was identified in one person and was not inherited from either parent (de novo).<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>De novo gene disruptions in children on the autistic spectrum Original research article by E.M. Iossifov et al. (2012). Read the abstract here. In this study, 343 families from the Simons Foundation\u2019s Simons Simplex Collection, who have at least one child with a diagnosis of autism, were tested with whole-exome sequencing. This study identified 350-400 [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":532,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6231"}],"collection":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/comments?post=6231"}],"version-history":[{"count":1,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6231\/revisions"}],"predecessor-version":[{"id":6232,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6231\/revisions\/6232"}],"up":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/532"}],"wp:attachment":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/media?parent=6231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}