{"id":6218,"date":"2019-09-27T07:46:25","date_gmt":"2019-09-27T11:46:25","guid":{"rendered":"https:\/\/www.simonssearchlight.org\/?page_id=6218"},"modified":"2019-09-27T07:46:25","modified_gmt":"2019-09-27T11:46:25","slug":"6218-2","status":"publish","type":"page","link":"https:\/\/www.simonssearchlight.org\/research\/what-we-study\/mbd5-2\/6218-2\/","title":{"rendered":""},"content":{"rendered":"<h2><strong>Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations<\/strong><\/h2>\n<p>Original research article by B.J. O\u2019Roak <em>et al.<\/em> (2012).<\/p>\n<p>Read the abstract <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22495309\">here<\/a>.<\/p>\n<p>Whole-exome sequencing was performed for 209 families (677 people) who had participated in the <span class=\"notranslate\">Simons Foundation<\/span>\u2019s Simons Simplex Collection. The study included children with autism and intellectual disability. This study identified over 100 new candidate genes related to developmental delay, intellectual disability, and\/or features of autism, including the\u00a0MBD5\u00a0gene (a gene known to be involved in causing intellectual disability) that was not inherited from either parent.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations Original research article by B.J. O\u2019Roak et al. (2012). Read the abstract here. Whole-exome sequencing was performed for 209 families (677 people) who had participated in the Simons Foundation\u2019s Simons Simplex Collection. The study included children with autism and intellectual disability. This [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":530,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6218"}],"collection":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/comments?post=6218"}],"version-history":[{"count":1,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6218\/revisions"}],"predecessor-version":[{"id":6219,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6218\/revisions\/6219"}],"up":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/530"}],"wp:attachment":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/media?parent=6218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}