{"id":6131,"date":"2019-09-25T10:45:16","date_gmt":"2019-09-25T14:45:16","guid":{"rendered":"https:\/\/www.simonssearchlight.org\/?page_id=6131"},"modified":"2019-09-25T10:45:16","modified_gmt":"2019-09-25T14:45:16","slug":"6131-2","status":"publish","type":"page","link":"https:\/\/www.simonssearchlight.org\/research\/what-we-study\/foxp1-2\/6131-2\/","title":{"rendered":""},"content":{"rendered":"<h2><strong>Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders<\/strong><\/h2>\n<p>Original research article by B.K. O&#8217;Roak\u00a0<em>et al<\/em>. (2012)<\/p>\n<p>Read the abstract <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23160955\">here<\/a>.<\/p>\n<p>The authors of this study used genetic material from 2,446 people in the Simon Simplex Collection (SSC) to look for 44 genes that have been associated with autism. The SSC includes children with autism and intellectual disability. This study identified over 100 new candidate genes related to developmental delay, intellectual disability and\/or features of autism.\u00a0 Mutations in only two genes \u2013 CHD8 and NTNG1 &#8211; were found in more than one person, and further analysis of six specific genes (FOXP1, GRIN2B, LAMC3, SCN1A, FOXP2 and GRIN2A) found additional mutations in three of the genes \u2013 GRIN2B, LAMC3 and SCN1A &#8211; suggesting that there are many various genetic causes of autism and intellectual disability.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders Original research article by B.K. O&#8217;Roak\u00a0et al. (2012) Read the abstract here. The authors of this study used genetic material from 2,446 people in the Simon Simplex Collection (SSC) to look for 44 genes that have been associated with autism. The SSC includes children [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":497,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6131"}],"collection":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/comments?post=6131"}],"version-history":[{"count":1,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6131\/revisions"}],"predecessor-version":[{"id":6132,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6131\/revisions\/6132"}],"up":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/497"}],"wp:attachment":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/media?parent=6131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}