{"id":6042,"date":"2019-09-24T07:31:26","date_gmt":"2019-09-24T11:31:26","guid":{"rendered":"https:\/\/www.simonssearchlight.org\/?page_id=6042"},"modified":"2019-09-24T12:16:01","modified_gmt":"2019-09-24T16:16:01","slug":"6042-2","status":"publish","type":"page","link":"https:\/\/www.simonssearchlight.org\/research\/what-we-study\/chd8-2\/6042-2\/","title":{"rendered":""},"content":{"rendered":"<h2><strong>Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations<\/strong><\/h2>\n<p>Original Research Article by B. O&#8217;Roak\u00a0<em>et al.<\/em> (2012).<\/p>\n<p>Read the article <a href=\"https:\/\/www.nature.com\/articles\/nature10989\">here<\/a>.<\/p>\n<p>In this study, researchers examined 2,494 samples from the <span class=\"notranslate\">Simons Foundation<\/span>\u2019s Simons Simplex Collection for changes in 44 genes that have been associated with autism and intellectual disability. The study found 27 de novo (not inherited from either parent) changes in 16 genes, including changes in <em>CHD8<\/em> in eight children. Six of the children have larger-than-average head sizes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations Original Research Article by B. O&#8217;Roak\u00a0et al. (2012). Read the article here. In this study, researchers examined 2,494 samples from the Simons Foundation\u2019s Simons Simplex Collection for changes in 44 genes that have been associated with autism and intellectual disability. The study [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":425,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6042"}],"collection":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/comments?post=6042"}],"version-history":[{"count":2,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6042\/revisions"}],"predecessor-version":[{"id":6086,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6042\/revisions\/6086"}],"up":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/425"}],"wp:attachment":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/media?parent=6042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}