{"id":6017,"date":"2019-09-23T13:39:28","date_gmt":"2019-09-23T17:39:28","guid":{"rendered":"https:\/\/www.simonssearchlight.org\/?page_id=6017"},"modified":"2019-09-24T11:29:03","modified_gmt":"2019-09-24T15:29:03","slug":"6017-2","status":"publish","type":"page","link":"https:\/\/www.simonssearchlight.org\/research\/what-we-study\/chd2-2\/6017-2\/","title":{"rendered":""},"content":{"rendered":"<h2><strong>De novo mutations in the classic epileptic encephalopathies<\/strong><\/h2>\n<p>Original research article by Epi4K and EPGP investigators.<\/p>\n<p>Read the article <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3773011\/\">here<\/a>.<\/p>\n<p>The exomes, which make up 1% of the genome, of 264 \u201ctrios\u201d (a child with epilepsy and both birth parents) were sequenced to seek a genetic cause for infantile spasms and another seizure disorder called Lennox-Gastaut syndrome. This study found over 300 gene changes that were not inherited from either parent, including a change in <em>CHD2<\/em> in one child. This child had myoclonic seizures beginning at age 6 months and was developmentally delayed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>De novo mutations in the classic epileptic encephalopathies Original research article by Epi4K and EPGP investigators. Read the article here. The exomes, which make up 1% of the genome, of 264 \u201ctrios\u201d (a child with epilepsy and both birth parents) were sequenced to seek a genetic cause for infantile spasms and another seizure disorder called [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":423,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6017"}],"collection":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/comments?post=6017"}],"version-history":[{"count":2,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6017\/revisions"}],"predecessor-version":[{"id":6081,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/6017\/revisions\/6081"}],"up":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/423"}],"wp:attachment":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/media?parent=6017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}