{"id":5895,"date":"2019-09-18T13:48:37","date_gmt":"2019-09-18T17:48:37","guid":{"rendered":"https:\/\/www.simonssearchlight.org\/?page_id=5895"},"modified":"2019-09-18T13:49:27","modified_gmt":"2019-09-18T17:49:27","slug":"clinical-whole-exome-sequencing-for-the-diagnosis-of-mendelian-disorders","status":"publish","type":"page","link":"https:\/\/www.simonssearchlight.org\/research\/what-we-study\/ankrd11-old\/clinical-whole-exome-sequencing-for-the-diagnosis-of-mendelian-disorders\/","title":{"rendered":""},"content":{"rendered":"<h2><strong>Clinical whole-exome sequencing for the diagnosis of Mendelian disorders<\/strong><\/h2>\n<p>Original research article by Y. Yang <em>et al. <\/em>(2013).<\/p>\n<p>Read the article <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1306555\">here<\/a>.<\/p>\n<p>In this study, a test called whole-exome sequencing was used to search for genetic causes to unexplained developmental delay, intellectual disability, and neurological differences in 250 children. One child had a change in the\u00a0<em>ANKRD11<\/em>\u00a0gene that is believed to be the cause of his intellectual disability.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clinical whole-exome sequencing for the diagnosis of Mendelian disorders Original research article by Y. Yang et al. (2013). Read the article here. In this study, a test called whole-exome sequencing was used to search for genetic causes to unexplained developmental delay, intellectual disability, and neurological differences in 250 children. One child had a change in [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":404,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/5895"}],"collection":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/comments?post=5895"}],"version-history":[{"count":3,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/5895\/revisions"}],"predecessor-version":[{"id":5898,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/5895\/revisions\/5898"}],"up":[{"embeddable":true,"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/pages\/404"}],"wp:attachment":[{"href":"https:\/\/www.simonssearchlight.org\/wp-json\/wp\/v2\/media?parent=5895"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}